Vulnerability-Lookup

PYSEC-2026-1221

Vulnerability from pysec - Published: 2026-07-07 16:03 - Updated: 2026-07-07 17:23

Details

Bio.Entrez in Biopython through 1.86 allows doctype XXE.

Severity

4.9 (Medium)


                  
                    CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L

Impacted products

Name	purl
biopython	pkg:pypi/biopython

Aliases

JSON

To clipboard

{
  "affected": [
    {
      "package": {
        "ecosystem": "PyPI",
        "name": "biopython",
        "purl": "pkg:pypi/biopython"
      },
      "ranges": [
        {
          "events": [
            {
              "introduced": "0"
            },
            {
              "fixed": "1.87"
            }
          ],
          "type": "ECOSYSTEM"
        }
      ],
      "versions": [
        "1.00a3",
        "1.00a4",
        "1.10",
        "1.20",
        "1.21",
        "1.22",
        "1.23",
        "1.24",
        "1.30",
        "1.40b",
        "1.41",
        "1.42",
        "1.43",
        "1.44",
        "1.45",
        "1.46",
        "1.47",
        "1.48",
        "1.49",
        "1.49b",
        "1.50",
        "1.50b",
        "1.51",
        "1.51b",
        "1.52",
        "1.53",
        "1.54",
        "1.54b",
        "1.55",
        "1.55b",
        "1.56",
        "1.57",
        "1.58",
        "1.59",
        "1.60",
        "1.61",
        "1.62",
        "1.62b",
        "1.63",
        "1.63b",
        "1.64",
        "1.65",
        "1.66",
        "1.67",
        "1.68",
        "1.69",
        "1.70",
        "1.71",
        "1.72",
        "1.73",
        "1.74",
        "1.75",
        "1.76",
        "1.77",
        "1.78",
        "1.79",
        "1.80",
        "1.81",
        "1.82",
        "1.83",
        "1.84",
        "1.85",
        "1.86"
      ]
    }
  ],
  "aliases": [
    "CVE-2025-68463",
    "GHSA-x3vf-39hj-gxr4"
  ],
  "details": "Bio.Entrez in Biopython through 1.86 allows doctype XXE.",
  "id": "PYSEC-2026-1221",
  "modified": "2026-07-07T17:23:51.516853Z",
  "published": "2026-07-07T16:03:13.322865Z",
  "references": [
    {
      "type": "ADVISORY",
      "url": "https://nvd.nist.gov/vuln/detail/CVE-2025-68463"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython/issues/5109"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython/blob/master/NEWS.rst"
    },
    {
      "type": "WEB",
      "url": "https://pypi.org/project/biopython/1.87"
    },
    {
      "type": "WEB",
      "url": "http://www.openwall.com/lists/oss-security/2026/05/08/16"
    },
    {
      "type": "PACKAGE",
      "url": "https://pypi.org/project/biopython"
    },
    {
      "type": "ADVISORY",
      "url": "https://github.com/advisories/GHSA-x3vf-39hj-gxr4"
    }
  ],
  "severity": [
    {
      "score": "CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L",
      "type": "CVSS_V3"
    }
  ],
  "summary": "Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez"
}

CVE-2025-68463 (GCVE-0-2025-68463)

Vulnerability from cvelistv5 – Published: 2025-12-18 05:40 – Updated: 2026-05-08 18:28

Summary

Bio.Entrez in Biopython through 186 allows doctype XXE.

Severity

4.9 (Medium)


                        
                          CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L

SSVC

Exploitation: none Automatable: no Technical Impact: partial

CISA Coordinator (v2.0.3)

CWE

CWE-611 - Improper Restriction of XML External Entity Reference

Assigner

mitre

References

5 references

URL	Tags
https://github.com/biopython/biopython/issues/5109
https://pypi.org/project/biopython/1.87/
https://github.com/biopython/biopython/blob/maste…
https://github.com/biopython/biopython/commit/736…
http://www.openwall.com/lists/oss-security/2026/0…

Impacted products

1 product

Vendor	Product	Version
Biopython	Biopython	Affected: 0 , ≤ 186 (custom)

Show details on NVD website

JSON

To clipboard

{
  "containers": {
    "adp": [
      {
        "metrics": [
          {
            "other": {
              "content": {
                "id": "CVE-2025-68463",
                "options": [
                  {
                    "Exploitation": "none"
                  },
                  {
                    "Automatable": "no"
                  },
                  {
                    "Technical Impact": "partial"
                  }
                ],
                "role": "CISA Coordinator",
                "timestamp": "2025-12-18T21:34:53.073126Z",
                "version": "2.0.3"
              },
              "type": "ssvc"
            }
          }
        ],
        "providerMetadata": {
          "dateUpdated": "2025-12-18T21:34:56.969Z",
          "orgId": "134c704f-9b21-4f2e-91b3-4a467353bcc0",
          "shortName": "CISA-ADP"
        },
        "title": "CISA ADP Vulnrichment"
      },
      {
        "providerMetadata": {
          "dateUpdated": "2026-05-08T18:28:47.889Z",
          "orgId": "af854a3a-2127-422b-91ae-364da2661108",
          "shortName": "CVE"
        },
        "references": [
          {
            "url": "http://www.openwall.com/lists/oss-security/2026/05/08/16"
          }
        ],
        "title": "CVE Program Container"
      }
    ],
    "cna": {
      "affected": [
        {
          "defaultStatus": "unknown",
          "packageURL": "pkg:pypi/biopython",
          "product": "Biopython",
          "vendor": "Biopython",
          "versions": [
            {
              "lessThanOrEqual": "186",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        }
      ],
      "descriptions": [
        {
          "lang": "en",
          "value": "Bio.Entrez in Biopython through 186 allows doctype XXE."
        }
      ],
      "metrics": [
        {
          "cvssV3_1": {
            "attackComplexity": "HIGH",
            "attackVector": "NETWORK",
            "availabilityImpact": "LOW",
            "baseScore": 4.9,
            "baseSeverity": "MEDIUM",
            "confidentialityImpact": "LOW",
            "integrityImpact": "NONE",
            "privilegesRequired": "LOW",
            "scope": "CHANGED",
            "userInteraction": "NONE",
            "vectorString": "CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L",
            "version": "3.1"
          },
          "format": "CVSS",
          "scenarios": [
            {
              "lang": "en",
              "value": "GENERAL"
            }
          ]
        }
      ],
      "problemTypes": [
        {
          "descriptions": [
            {
              "cweId": "CWE-611",
              "description": "CWE-611 Improper Restriction of XML External Entity Reference",
              "lang": "en",
              "type": "CWE"
            }
          ]
        }
      ],
      "providerMetadata": {
        "dateUpdated": "2026-04-22T17:00:16.865Z",
        "orgId": "8254265b-2729-46b6-b9e3-3dfca2d5bfca",
        "shortName": "mitre"
      },
      "references": [
        {
          "url": "https://github.com/biopython/biopython/issues/5109"
        },
        {
          "url": "https://pypi.org/project/biopython/1.87/"
        },
        {
          "url": "https://github.com/biopython/biopython/blob/master/NEWS.rst"
        },
        {
          "url": "https://github.com/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d"
        }
      ],
      "x_generator": {
        "engine": "CVE-Request-form 0.0.1"
      }
    }
  },
  "cveMetadata": {
    "assignerOrgId": "8254265b-2729-46b6-b9e3-3dfca2d5bfca",
    "assignerShortName": "mitre",
    "cveId": "CVE-2025-68463",
    "datePublished": "2025-12-18T05:40:36.842Z",
    "dateReserved": "2025-12-18T05:40:36.580Z",
    "dateUpdated": "2026-05-08T18:28:47.889Z",
    "state": "PUBLISHED"
  },
  "dataType": "CVE_RECORD",
  "dataVersion": "5.2"
}

GHSA-X3VF-39HJ-GXR4

Vulnerability from github – Published: 2025-12-18 06:30 – Updated: 2026-05-12 13:37

Summary

Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez

Details

Bio.Entrez in Biopython through 1.86 allows doctype XXE.

Severity

4.9 (Medium)


                  
                    CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L

Show details on source website

JSON

To clipboard

{
  "affected": [
    {
      "package": {
        "ecosystem": "PyPI",
        "name": "biopython"
      },
      "ranges": [
        {
          "events": [
            {
              "introduced": "0"
            },
            {
              "last_affected": "1.86"
            }
          ],
          "type": "ECOSYSTEM"
        }
      ]
    }
  ],
  "aliases": [
    "CVE-2025-68463"
  ],
  "database_specific": {
    "cwe_ids": [
      "CWE-611"
    ],
    "github_reviewed": true,
    "github_reviewed_at": "2025-12-18T22:16:29Z",
    "nvd_published_at": "2025-12-18T06:15:50Z",
    "severity": "MODERATE"
  },
  "details": "Bio.Entrez in Biopython through 1.86 allows doctype XXE.",
  "id": "GHSA-x3vf-39hj-gxr4",
  "modified": "2026-05-12T13:37:18Z",
  "published": "2025-12-18T06:30:13Z",
  "references": [
    {
      "type": "ADVISORY",
      "url": "https://nvd.nist.gov/vuln/detail/CVE-2025-68463"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython/issues/5109"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython"
    },
    {
      "type": "WEB",
      "url": "https://github.com/biopython/biopython/blob/master/NEWS.rst"
    },
    {
      "type": "WEB",
      "url": "https://pypi.org/project/biopython/1.87"
    },
    {
      "type": "WEB",
      "url": "http://www.openwall.com/lists/oss-security/2026/05/08/16"
    }
  ],
  "schema_version": "1.4.0",
  "severity": [
    {
      "score": "CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L",
      "type": "CVSS_V3"
    }
  ],
  "summary": "Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez"
}

Sightings

Author	Source	Type	Date	Other

Nomenclature

Seen: The vulnerability was mentioned, discussed, or observed by the user.
Confirmed: The vulnerability has been validated from an analyst's perspective.
Published Proof of Concept: A public proof of concept is available for this vulnerability.
Exploited: The vulnerability was observed as exploited by the user who reported the sighting.
Patched: The vulnerability was observed as successfully patched by the user who reported the sighting.
Not exploited: The vulnerability was not observed as exploited by the user who reported the sighting.
Not confirmed: The user expressed doubt about the validity of the vulnerability.
Not patched: The vulnerability was not observed as successfully patched by the user who reported the sighting.

Detection rules are retrieved from Rulezet.

Action not permitted

PYSEC-2026-1221

CVE-2025-68463 (GCVE-0-2025-68463)

GHSA-X3VF-39HJ-GXR4

Tags

Sightings

Nomenclature